院長紹介

院長あいさつ

全ての方のホームドクターとして信頼されるよう、地域に貢献してまいります。
総合内科専門医として、一般内科の診療から、「おなかのスペシャリスト」として、私の専門中の専門である消化管内視鏡検査・治療(胃カメラ、大腸カメラ、日帰り大腸ポリープ手術)まで丁寧に幅広く診療し、地域のみなさまが健康に笑顔で過ごせるよう、サポートいたします。
私は東京大学医学部医学科を卒業後、東京大学医学部附属病院、JR東京総合病院、日本赤十字社医療センターで経験を積み、医学博士号を取得、生活習慣病の診療・研究で有名な朝日生命成人病研究所で消化器内科部長を務めました。その後ニューヨークのコロンビア大学への留学を経て、「苦痛の少ない内視鏡を普及させ、胃や大腸の病気の早期発見・早期治療に力を尽くしたい」と考え、当クリニックを開院いたしました。
私の医師としての目標は「がんで亡くなる人をゼロにする」ことです。がん死因の多くを占める胃がん・大腸がんは、早期発見・早期治療により「治す」ことのできる時代です。そのためには定期的に内視鏡検査を受けていただくことが大切です。
当院では、検査を受ける患者様の苦痛を最小限にしながら、世界トップレベルの内視鏡検査を提供し、病気の予防・早期発見・早期治療を行います。また、検査の必要性をご納得いただけるように、検査前には「どのような検査なのか」、検査後には「検査の結果」について、わかりやすい説明をいたします。「苦痛の少ない」胃カメラ・大腸内視鏡を受けていただくことで、定期的に内視鏡検査を受けたいと思っていただき、地域で「がんで亡くなる方がいなくなる」ことを目指しています。

当院の理念は

  1. ひとりひとりの患者様を大切にし、地域に貢献すること
  2. 高度な知識、技術、人間性を備えたプロフェッショナルであること
  3. 患者様から学んだことを次の世代に還元すること

です。患者様に寄り添った上質な医療を提供するよう、スタッフ一同努めてまいります。さきたに内科・内視鏡クリニックをどうぞよろしくお願いいたします。

院長 崎谷 康佑

学歴

  • 私立武蔵高校卒業
  • 東京大学理科III類入学
  • 東京大学医学部医学科卒業
  • 東京大学大学院博士課程内科学専攻修了(医学博士)
  • 米国NYコロンビア大学留学(日本学術振興会特別研究員PD)

職歴

  • 東京大学医学部附属病院
  • JR東京総合病院
  • 日本赤十字社医療センター・消化器内科
  • 朝日生命成人病研究所附属医院・消化器内科部長
  • さきたに内科・内視鏡クリニック 開設
  • 習志野市医師会理事(成人保険分野)

資格・所属学会

論文・業績等

  1. Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers.
    Toyoshima O, Yoshida S, Nishizawa T, Toyoshima A, Sakitani K, Matsuno T, Yamada T, Matsuo T, Nakagawa H, Koike K.World J Gastrointest Endosc. 2021 Sep 16;13(9):426-436. doi: 10.4253/wjge.v13.i9.426.PMID: 34630892
  2. Consistency between the endoscopic Kyoto classification and pathological updated Sydney system for gastritis: A cross-sectional study.
    Toyoshima O, Nishizawa T, Yoshida S, Matsuno T, Odawara N, Toyoshima A, Sakitani K, Watanabe H, Fujishiro M, Suzuki H.J Gastroenterol Hepatol. 2022 Feb;37(2):291-300. doi: 10.1111/jgh.15693. Epub 2021 Oct 6.PMID: 34569096
  3. Comparison of endoscopic gastritis based on Kyoto classification between diffuse and intestinal gastric cancer.
    Toyoshima O, Nishizawa T, Yoshida S, Aoki T, Nagura F, Sakitani K, Tsuji Y, Nakagawa H, Suzuki H, Koike K.World J Gastrointest Endosc. 2021 May 16;13(5):125-136. doi: 10.4253/wjge.v13.i5.125.PMID: 34046150
  4. Helicobacter pylori eradication improved the Kyoto classification score on endoscopy.
    Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Takahashi Y, Kinoshita K, Torii A, Yamada A, Suzuki H, Koike K.JGH Open. 2020 May 29;4(5):909-914. doi: 10.1002/jgh3.12360. eCollection 2020 Oct.PMID: 33102763
  5. Kyoto classification in patients who developed multiple gastric carcinomas after Helicobacter pylori eradication.
    Sakitani K, Nishizawa T, Toyoshima A, Yoshida S, Matsuno T, Yamada T, Irokawa M, Takahashi Y, Nakai Y, Toyoshima O, Koike K.World J Gastrointest Endosc. 2020 Sep 16;12(9):276-284. doi: 10.4253/wjge.v12.i9.276.PMID: 32994858
  6. Clinical features of cardiac nodularity-like appearance induced by Helicobacter pylori infection.
    Nishizawa T, Sakitani K, Suzuki H, Yoshida S, Kataoka Y, Nakai Y, Ebinuma H, Kanai T, Toyoshima O, Koike K.World J Gastroenterol. 2020 Sep 21;26(35):5354-5361. doi: 10.3748/wjg.v26.i35.5354.PMID: 32994693
  7. Colonoscopy using back brace support belt: A randomized, prospective trial.
    Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Yoshida S, Fukagawa K, Hata K, Ishihara S, Suzuki H.JGH Open. 2019 Nov 7;4(3):441-445. doi: 10.1002/jgh3.12276. eCollection 2020 Jun.PMID: 32514451 
  8. Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Watanabe H, Yoshida S, Nakai Y, Hata K, Ebinuma H, Suzuki H, Koike K.Endosc Int Open. 2020 Jun;8(6):E770-E774. doi: 10.1055/a-1136-9890. Epub 2020 May 25.PMID: 32490162 
  9. Adverse events associated with bidirectional endoscopy with midazolam and pethidine.
    Nishizawa T, Sakitani K, Suzuki H, Takeuchi M, Takahashi Y, Takeuchi K, Yamakawa T, Yoshida S, Hata K, Ebinuma H, Koike K, Toyoshima O.J Clin Biochem Nutr. 2020 Jan;66(1):78-81. doi: 10.3164/jcbn.19-73. Epub 2019 Oct 30.PMID: 32001961 
  10.  Small-caliber endoscopes are more fragile than conventional endoscopes.
    Nishizawa T, Sakitani K, Suzuki H, Yamakawa T, Takahashi Y, Yoshida S, Nakai Y, Hata K, Ebinuma H, Koike K, Toyoshima O.Endosc Int Open. 2019 Dec;7(12):E1729-E1732. doi: 10.1055/a-1036-6186. Epub 2019 Dec 10.PMID: 31828209
  11. CF290 for pancolonic chromoendoscopy improved sessile serrated polyp detection and procedure time: a propensity score-matching study.
    Toyoshima O, Yoshida S, Nishizawa T, Yamakawa T, Sakitani K, Hata K, Takahashi Y, Fujishiro M, Watanabe H, Koike K.Endosc Int Open. 2019 Aug;7(8):E987-E993. doi: 10.1055/a-0953-1909. Epub 2019 Jul 24.PMID: 31367679 
  12. A combination of serum anti-Helicobacter pylori antibody titer and Kyoto classification score could provide a more accurate diagnosis of H pylori.
    Nishizawa T, Sakitani K, Suzuki H, Yamakawa T, Takahashi Y, Yamamichi N, Watanabe H, Seto Y, Koike K, Toyoshima O.United European Gastroenterol J. 2019 Apr;7(3):343-348. doi: 10.1177/2050640619825947. Epub 2019 Jan 15.PMID: 31019702 
  13. Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study.
    Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Takahashi Y, Yamamichi N, Hata K, Seto Y, Koike K, Watanabe H, Suzuki H.World J Gastroenterol. 2018 Sep 21;24(35):4061-4068. doi: 10.3748/wjg.v24.i35.4061.PMID: 30254410 
  14. Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance.
    Sakitani K, Nishizawa T, Arita M, Yoshida S, Kataoka Y, Ohki D, Yamashita H, Isomura Y, Toyoshima A, Watanabe H, Iizuka T, Saito Y, Fujisaki J, Yahagi N, Koike K, Toyoshima O.Helicobacter. 2018 Aug;23(4):e12503. doi: 10.1111/hel.12503. Epub 2018 Jun 20.PMID: 29924436
  15. Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease.
    Ihara S, Hirata Y, Hikiba Y, Yamashita A, Tsuboi M, Hata M, Konishi M, Suzuki N, Sakitani K, Kinoshita H, Hayakawa Y, Nakagawa H, Ijichi H, Tateishi K, Koike K.J Crohns Colitis. 2018 Nov 9;12(10):1219-1231. doi: 10.1093/ecco-jcc/jjy088.PMID: 29917067
  16. Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice.
    Shibata W, Kinoshita H, Hikiba Y, Sato T, Ishii Y, Sue S, Sugimori M, Suzuki N, Sakitani K, Ijichi H, Mori R, Endo I, Maeda S.Sci Rep. 2018 Apr 18;8(1):6150. doi: 10.1038/s41598-018-24375-2.PMID: 29670173
  17. Helicobacter pylori infection in subjects negative for high titer serum antibody.
    Toyoshima O, Nishizawa T, Arita M, Kataoka Y, Sakitani K, Yoshida S, Yamashita H, Hata K, Watanabe H, Suzuki H.World J Gastroenterol. 2018 Apr 7;24(13):1419-1428. doi: 10.3748/wjg.v24.i13.1419.PMID: 29632423
  18. Decline in perception of acid regurgitation symptoms from gastroesophageal reflux disease in diabetes mellitus patients.
    Sakitani K, Suzuki N, Ihara S, Hirata Y, Kawazu S, Iwamoto Y, Koike K.PLoS One. 2018 Mar 15;13(3):e0194466. doi: 10.1371/journal.pone.0194466. eCollection 2018.PMID: 29543865
  19. Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis.
    Toyoshima O, Tanikawa C, Yamamoto R, Watanabe H, Yamashita H, Sakitani K, Yoshida S, Kubo M, Matsuo K, Ito H, Koike K, Seto Y, Matsuda K.Oncotarget. 2017 Dec 14;9(3):3936-3945. doi: 10.18632/oncotarget.23278. eCollection 2018 Jan 9.PMID: 29423095
  20. CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development.
    Sakitani K, Hayakawa Y, Deng H, Ariyama H, Kinoshita H, Konishi M, Ono S, Suzuki N, Ihara S, Niu Z, Kim W, Tanaka T, Liu H, Chen X, Tailor Y, Fox JG, Konieczny SF, Onodera H, Sepulveda AR, Asfaha S, Hirata Y, Worthley DL, Koike K, Wang TC.Oncotarget. 2017 Nov 10;8(67):111012-111025. doi: 10.18632/oncotarget.22451. eCollection 2017 Dec 19.PMID: 29340033
  21. Clinical characteristics of patients with diabetes mellitus and fatty liver diagnosed by liver/spleen Hounsfield units on CT scan.
    Sakitani K, Enooku K, Kubo H, Tanaka A, Arai H, Kawazu S, Koike K.J Int Med Res. 2017 Jun;45(3):1208-1220. doi: 10.1177/0300060517707672. Epub 2017 May 28.PMID: 28553763
  22. Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection.
    Nishizawa T, Suzuki H, Sakitani K, Yamashita H, Yoshida S, Hata K, Kanazawa T, Fujiwara N, Kanai T, Yahagi N, Toyoshima O.United European Gastroenterol J. 2017 Feb;5(1):32-36. doi: 10.1177/2050640616642341. Epub 2016 Jun 22.PMID: 28405319
  23. The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis.
    Jin G, Sakitani K, Wang H, Jin Y, Dubeykovskiy A, Worthley DL, Tailor Y, Wang TC.Oncotarget. 2017 Jun 20;8(25):40606-40619. doi: 10.18632/oncotarget.16506.PMID: 28380450
  24. Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.
    Hayakawa Y 1, Sakitani K 1, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC.Cancer Cell. 2017 Jan 9;31(1):21-34. doi: 10.1016/j.ccell.2016.11.005. Epub 2016 Dec 15.PMID: 27989802. 1: co-first author
  25. Efficacy of triple therapy with esomeprazole, amoxicillin, and sitafloxacin as a third-line Helicobacter pylori eradication regimen.
    Hirata Y, Serizawa T, Shichijo S, Suzuki N, Sakitani K, Hayakawa Y, Yamada A, Koike K.Int J Infect Dis. 2016 Oct;51:66-69. doi: 10.1016/j.ijid.2016.08.019. Epub 2016 Aug 30.PMID: 27590563 
  26. TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota.
    Ihara S, Hirata Y, Serizawa T, Suzuki N, Sakitani K, Kinoshita H, Hayakawa Y, Nakagawa H, Ijichi H, Tateishi K, Koike K.J Immunol. 2016 Jun 1;196(11):4603-13. doi: 10.4049/jimmunol.1502548. Epub 2016 Apr 22.PMID: 27183608
  27. Gastric Metaplasia Induced by Helicobacter pylori Is Associated with Enhanced SOX9 Expression via Interleukin-1 Signaling.
    Serizawa T, Hirata Y, Hayakawa Y, Suzuki N, Sakitani K, Hikiba Y, Ihara S, Kinoshita H, Nakagawa H, Tateishi K, Koike K.Infect Immun. 2015 Dec 7;84(2):562-72. doi: 10.1128/IAI.01437-15. Print 2016 Feb.PMID: 26644382
  28. Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche.
    Hayakawa Y, Ariyama H, Stancikova J, Sakitani K, Asfaha S, Renz BW, Dubeykovskaya ZA, Shibata W, Wang H, Westphalen CB, Chen X, Takemoto Y, Kim W, Khurana SS, Tailor Y, Nagar K, Tomita H, Hara A, Sepulveda AR, Setlik W, Gershon MD, Saha S, Ding L, Shen Z, Fox JG, Friedman RA, Konieczny SF, Worthley DL, Korinek V, Wang TC.Cancer Cell. 2015 Dec 14;28(6):800-814. doi: 10.1016/j.ccell.2015.10.003. Epub 2015 Nov 12.PMID: 26585400 
  29. Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress.
    Sakitani K, Hirata Y, Hikiba Y, Hayakawa Y, Ihara S, Suzuki H, Suzuki N, Serizawa T, Kinoshita H, Sakamoto K, Nakagawa H, Tateishi K, Maeda S, Ikenoue T, Kawazu S, Koike K.BMC Cancer. 2015 Oct 24;15:795. doi: 10.1186/s12885-015-1789-5.PMID: 26496833 
  30. Gastric cancer diagnosed after Helicobacter pylori eradication in diabetes mellitus patients.
    Sakitani K, Hirata Y, Suzuki N, Shichijo S, Yanai A, Serizawa T, Sakamoto K, Akanuma M, Maeda S, Yamaji Y, Iwamoto Y, Kawazu S, Koike K.BMC Gastroenterol. 2015 Oct 21;15:143. doi: 10.1186/s12876-015-0377-0.PMID: 26486595 
  31. Neutrophil infiltration and the distribution of intestinal metaplasia is associated with metachronous gastric cancer following endoscopic submucosal dissection.
    Sugimoto T, Yamaji Y, Sakitani K, Isomura Y, Yoshida S, Yamada A, Hirata Y, Ogura K, Okamoto M, Koike K.Can J Gastroenterol Hepatol. 2015 Aug-Sep;29(6):321-5. doi: 10.1155/2015/950734. Epub 2015 Jun 12.PMID: 26069891 
  32. Distribution of intestinal metaplasia as a predictor of gastric cancer development.
    Shichijo S, Hirata Y, Sakitani K, Yamamoto S, Serizawa T, Niikura R, Watabe H, Yoshida S, Yamada A, Yamaji Y, Ushiku T, Fukayama M, Koike K.J Gastroenterol Hepatol. 2015 Aug;30(8):1260-4. doi: 10.1111/jgh.12946.PMID: 25777777
  33. Characterization of a new small bowel adenocarcinoma cell line and screening of anti-cancer drug against small bowel adenocarcinoma.
    Suzuki H, Hirata Y, Suzuki N, Ihara S, Sakitani K, Kobayashi Y, Kinoshita H, Hayakawa Y, Yamada A, Watabe H, Tateishi K, Ikenoue T, Yamaji Y, Koike K.Am J Pathol. 2015 Feb;185(2):550-62. doi: 10.1016/j.ajpath.2014.10.006. Epub 2014 Dec 2.PMID: 25478808
  34. Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.
    Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S.Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1090-5. doi: 10.1073/pnas.1322731111. Epub 2014 Jan 6.PMID: 24395807 
  35. Differential roles of ASK1 and TAK1 in Helicobacter pylori-induced cellular responses.
    Hayakawa Y, Hirata Y, Kinoshita H, Sakitani K, Nakagawa H, Nakata W, Takahashi R, Sakamoto K, Maeda S, Koike K.Infect Immun. 2013 Dec;81(12):4551-60. doi: 10.1128/IAI.00914-13. Epub 2013 Sep 30.PMID: 24082073
  36. Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis.
    Kinoshita H, Hirata Y, Nakagawa H, Sakamoto K, Hayakawa Y, Takahashi R, Nakata W, Sakitani K, Serizawa T, Hikiba Y, Akanuma M, Shibata W, Maeda S, Koike K.PLoS One. 2013 Apr 12;8(4):e60914. doi: 10.1371/journal.pone.0060914. Print 2013.PMID: 23593346
  37. Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer.
    Takahashi R, Hirata Y, Sakitani K, Nakata W, Kinoshita H, Hayakawa Y, Nakagawa H, Sakamoto K, Hikiba Y, Ijichi H, Moses HL, Maeda S, Koike K.Cancer Sci. 2013 Mar;104(3):337-44. doi: 10.1111/cas.12080. Epub 2013 Jan 24.PMID: 23237571
  38. Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer.
    Hayakawa Y, Hirata Y, Sakitani K, Nakagawa H, Nakata W, Kinoshita H, Takahashi R, Takeda K, Ichijo H, Maeda S, Koike K.Cancer Sci. 2012 Dec;103(12):2181-5. doi: 10.1111/cas.12024. Epub 2012 Oct 30.PMID: 23110662
  39. Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation.
    Sakitani K, Hirata Y, Hayakawa Y, Serizawa T, Nakata W, Takahashi R, Kinoshita H, Sakamoto K, Nakagawa H, Akanuma M, Yoshida H, Maeda S, Koike K.Infect Immun. 2012 Nov;80(11):3795-803. doi: 10.1128/IAI.00637-12. Epub 2012 Aug 13.PMID: 22890997 
  40. Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli.
    Sakamoto K, Hikiba Y, Nakagawa H, Hirata Y, Hayakawa Y, Kinoshita H, Nakata W, Sakitani K, Takahashi R, Akanuma M, Kamata H, Maeda S.Oncogene. 2013 Apr 4;32(14):1854-62. doi: 10.1038/onc.2012.192. Epub 2012 May 21.PMID: 22614018
  41. Sitafloxacin resistance in Helicobacter pylori isolates and sitafloxacin-based triple therapy as a third-line regimen in Japan.
    Hirata Y, Ohmae T, Yanai A, Sakitani K, Hayakawa Y, Yoshida S, Sugimoto T, Mitsuno Y, Akanuma M, Yamaji Y, Ogura K, Maeda S, Koike K.Int J Antimicrob Agents. 2012 Apr;39(4):352-5. doi: 10.1016/j.ijantimicag.2011.12.002. Epub 2012 Feb 7.PMID: 22321702
  42. Gastric cancer risk according to the distribution of intestinal metaplasia and neutrophil infiltration.
    Sakitani K, Hirata Y, Watabe H, Yamada A, Sugimoto T, Yamaji Y, Yoshida H, Maeda S, Omata M, Koike K.J Gastroenterol Hepatol. 2011 Oct;26(10):1570-5. doi: 10.1111/j.1440-1746.2011.06767.x.PMID: 21575058

研究に関しまして

当院では診療・医療技術の向上を目指した医学研究のため、診療により得られた情報を学会発表、研究で使用致します。

その場合、患者様の氏名・住所等の個人情報が、それらに掲載されることはありませんのでご安心ください。個人情報に関しては匿名化を行い適正に管理しております。

ご同意いただけない場合でも、患者様の診療に何ら影響することはなく、診療上の不利益をこうむることはありません。遠慮なくスタッフにお伝え下さいませ。